Powder Deposition and Sintering for a Two-Powder Approach to Solid Freeform Fabrication

A two-powder approach is presented where Fused Deposition modeling (FDM) is used to create a thin shell in the shape of the part to be fabricated. The shell is filled with powder of the part material and surrounded by a support powder that has a high sintering temperature. Upon compressing and sintering the shelVpowder system in a uniaxial hot press, the polymer shell burns out and the support powder compresses the part powder. The part powder consolidates into the desired part while the support material remains in powder form and can be easily removed. This paper presents results ofinitial experimental studies.Mechanical Engineerin

A Triple Key Resource Sharing Technique for Enterprise Cloud

The cloud is a competitive alternative to the general distributed resource sharing scheme with less cost and efficient and less maintenance overhead so most of the enterprises are choosing it. The cloud is the service being delivered from remote sites. Weather it is public, private, hybrid, community or inter-cloud, the physical location of the devices at the end points are servers, storage devices, computing devices, networking equipments and security systems that we interact with mobiles, computers, tablets using some applications from inside and outside of the enterprise. The enterprises have to register for the required resources in the cloud and can be utilized by the different members. It is problematic to maintain security and user privacy within the enterprise with traditional strategy. In my proposed system an efficient resource sharing is provided by using a technique ERST with three keys called Enterprise key, Manager key and member key along with the Biometric authentication. DOI: 10.17762/ijritcc2321-8169.150611

Parametric Non-linear programming approach for N-policy queues with infinite capacity

This paper proposes a procedure to construct the membership function of N-policy queue with infinite capacity.  By using mathematical programming we construct the membership function of the system performance measure in which arrival rate and service rate are fuzzy numbers.  Based on a-cut approach and Zadeh’s extension principle, the fuzzy queues are converted into a family of crisp queues.  Suitable real world example is exemplified to analyze N-policy fuzzy queues.  Extending this model to fuzzy environment it would have further more wider applications

Improved DC utilization using advanced modulation techniques with Z source Inverter

Generally, an inverter is required to convert DC power generated by PV cell into AC power. A multilevel inverter (MLI) can synthesizes a staircase waveform. In this paper, a comparative study is made on performance of 5-level Z Source H Bridge inverter by considering advanced pulse width Modulation (PWM) strategies. PWM strategies of proposed ZSI’s is quite similar to the traditional carried-based PWM control method, the only difference is that to turn null states into shoot through states and keep the active switching states unchanged, so that the reliability of the inverter is greatly improved because miss-gating can no longer destroy the circuit. Keywords: Z source Inverter; PWM Schemes; Shoot Through; Photo voltai

METHOD DEVELOPMENT AND VALIDATION OF ULTRAVIOLET-VISIBLE SPECTROSCOPIC METHOD FOR THE ESTIMATION OF HEPATITIS-C DRUGS - DACLATASVIR AND SOFOSBUVIR IN ACTIVE PHARMACEUTICAL INGREDIENT FORM

ABSTRACTObjective: The objective of the present work is to develop a simple, efficient, and reproducible spectrophotometric method for the quantitativeestimation of hepatitis-C drugs - Daclatasvir and Sofosbuvir in its active pharmaceutical ingredient (API) form.Methods: The developed ultraviolet spectrophotometric method for the quantitative estimation of hepatitis-C drugs - Daclatasvir and Sofosbuvir isbased on measurement of absorption at a wavelength maximum (λmax) of 317 and 261 nm using methanol as solvent.Results: The method was validated in terms of specificity, precision, linearity, accuracy, and robustness as per the ICH guidelines. The method wasfound to be linear in the range of 50-150% for Daclatasvir and in the range of 43-143% for Sofosbuvir. The percentage recovery values were in therange of 99.4-100.6% for Daclatasvir and in the range of 99.7-100.6% for Sofosbuvir at different concentration levels. Relative standard deviation forprecision and intermediate precision results were found to be <2%. The correlation coefficient value observed for Daclatasvir and Sofosbuvir drugsubstances was not <0.99, 0.99, respectively. Results obtained from the validation experiments prove that the developed method is quantified for theestimation of Daclatasvir and Sofosbuvir drug substances.Conclusion: The developed method can be successfully applied for routine analysis, quality control analysis, and also suitable for stability analysis ofDaclatasvir and Sofosbuvir in API form as per the regulatory requirements.Keywords: Daclatasvir, Sofosbuvir, Method development, Validation, Ultraviolet-visible spectrophotometry

A Hybrid Digital Watermarking Approach Using Wavelets and LSB

The present paper proposed a novel approach called Wavelet based Least Significant Bit Watermarking (WLSBWM) for high authentication, security and copyright protection. Alphabet Pattern (AP) approach is used to generate shuffled image in the first stage and Pell’s Cat Map (PCM) is used for providing more security and strong protection from attacks. PCM applied on each 5×5 sub images. A wavelet concept is used to reduce the dimensionality of the image until it equals to the size of the watermark image. Discrete Cosign Transform is applied in the first stage; later N level Discrete Wavelet Transform (DWT) is applied for reducing up to the size of the watermark image. The water mark image is inserted in LHn Sub band of the wavelet image using LSB concept. Simulation results show that the proposed technique produces better PSNR and similarity measure. The experimental results indicate that the present approach is more reliable and secure efficient.The robustness of the proposed scheme is evaluated against various image-processing attacks

STABILITY INDICATING REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF LABETALOL AND ITS DEGRADATION PRODUCTS IN TABLET DOSAGE FORMS

ABSTRACTObjective: The objective of the present work is to develop a simple, efficient, and reproducible stability indicating reverse phase high-performanceliquid chromatographic method for simultaneous determination labetalol and its degradation products in tablet dosage forms.Methods: The chromatographic separation of labetalol and its degradation products in tablets was carried out on Zorbax Eclipse Plus C-18(100 × 4.6 mm, 3.5 µm) column using 0.1% trifluoroacetic acid (TFA) (v/v) in 1000 ml of water and 0.1% TFA (v/v) in 1000 ml of acetonitrile:Methanol (1:1) by linear gradient program. Flow rate was 1.0 mL min with a column temperature of 35°C, and detection wavelength was carried outat 230 nm. Known impurity is well resolved from the main active drug within 14 minutes run time.−1Results: The forced degradation studies were performed on labetalol tablets under acidic, basic, oxidation, thermal, humidity, and photolyticconditions. No degradation products were observed from the forced degradation studies, and the known impurity is well resolved from the mainactive drug. The method was validated in terms of specificity, linearity, limit of detection (LOD), limit of quantitation (LOQ), accuracy, precision, androbustness as per the ICH guidelines. The method was found to be linear in the range of LOQ to 120% for all the known and unknown impurities.The LOD and LOQ values of known impurity were found between 0.3593 and 0.7187 µg mL, and the percentage recovery values were in the rangeof 95.5-105.2% at different concentration levels. Relative standard deviation for precision and intermediate precision results were found to be <5%.The correlation coefficient found for all compounds was not <0.99. The results obtained from the validation experiments prove that the developedmethod is a stability indicating method.−1Conclusion: The developed method can be successfully applied for routine analysis, quality control analysis and also suitable for stability analysis ofthe simultaneous determination of labetalol and its degradation products in tablet dosage forms as per the regulatory requirements.Keywords: Labetalol, Development, Validation, Reverse phase high-performance liquid chromatography